Title : A bioinformatic approach to treating and preventing chronic inflammation with healthy plant-based diet
Abstract:
Inflammation is associated with a wide range of medical conditions including autoimmune diseases (e.g., rheumatoid arthritis), asthma, obesity, cardiovascular disease, atherosclerosis, diabetes, certain cancers, Alzheimer’s, and many more. It is involved in many leading causes of deaths throughout the world with high associated costs. We have researched the dietary effects and treatment of inflammation as part of our general strategic use of healthy plant-based diet (e.g., blueberries, olive oil and green tea ) to alter disease-causing genes and protein expression back toward the normal to potentially help treat and prevent various medical conditions. We call this approach “Dietary Rational Gene Targeting” and it has recently progressed to our creation of an online dietary guide prototype app that we call “Eat4Genes”. Dietary Rational Gene Targeting is an extension of nutrigenomic studies offering numerous advantages over pharmaceutical drug treatment including significantly lower cost, heathier treatment, and easy application in some cases requiring only simple dietary modification. Here we extend our prior Dietary Rational Gene Targeting mining analyses to an anti-inflammatory focus including expanding to more plant-based dietary agents, more inflammation markers, using a multi-omics approach, applying an improved weighted system, de-emphasizing studies using high botanical concentrations, including National Health and Nutrition Examination Survey (NHANES) data, and considering contributions from other dietary inflammatory indices toward integrating this information into our Eat4Genes site. Combined, we expect that these studies will culminate in significantly improved inflammatory dietary predictors of the risk of various disorders as well as associated dietary guidance, in turn significantly improving human health.
Audience Take Away Notes:
- A new natural therapy perspective toward educating the audience about new benefits of healthy diets.
- A new type of translational approach that students, patients, community, medical providers and researchers can use for education and dietary suggestion purposes.
- An emphasis on the use of our dietary strategy to treat inflammation-related disorders due to inflammation’s association with a wide-range of medical conditions and leading causes of death in parts of the world.
